Written by: Catharine Paddock, PhD” “Antibiotic resistance is a growing concern across the globe; last year, the World Health Organization warned that we are heading toward a “post-antibiotic era” unless more is done to tackle the problem.
Booth agrees, and says solitude may “be sought for deep growth experiences such as meditation, visualization, listening to music, and other forms of ‘doing nothing’ “. Another point that Booth makes is that you can still be lonely and have lots of connections with others. It is the quality of those connections that matter: “some lonely people have sufficient interactional networks and are, nonetheless, lonely because they are dissatisfied with those networks”.”, This is like another idea that is being increasingly questioned: that people who are single are lonely compared to people who are married., A study by psychologists from Lafayette College and the University of Miami shows that single people over 40 who have never married can be just as resilient as their married peers. The study challenges the idea that marriage is always best for your health.,” Lead author Jamila Bookwala, associate professor of psychology at Lafayette, said in a statement reported by Newsweek in December 2009 that: “When single people feel control over their lives and can rely on themselves, they can have especially high levels of happiness.” But the married people who reported being very self-sufficient weren’t necessarily happy about it, whearas the single people on average, felt relatively happy about it, she said. Bella DePaulo, a visiting professor at the University of California at Santa Barbara, who wrote the book “Singled Out: How Singles are Stereotyped, Stigmatized and Ignored and Still Live Happily Ever After”, told Newsweek that: “I think that it’s finally coming into our understanding that single life has changed and that it’s possible to live a complete, satisfying life as a single person”.”, It also seems that a problem with the early research on singletons was that they were often grouped together with widowed and divorced people. ,” So, if we find ourselves in a state of loneliness, and we know it is not “voluntary solitude”, what can we do about it? The UK mental health charity MIND, offers these suggestions for overcoming loneliness, which they say is possible if you are really determined to work at it: “” They also suggest that talking to a counsellor or psychotherapist might be a safe way to explore and understand problems, and find the courage and support to deal with situations that feel defeating. Such talking therapies can help people for the first time build self-acceptance and confidence, and from there find out that relating to others can be enjoyable and satisfying. And if none of these suggestions seem to fit what you are looking for, don’t despair, because as Emily White says in her blog, despite some attempts by the media to portray loneliness as “some sort of freakish, dangerous disease state”, it’s not.https://harmoniqhealth.com/ Loneliness, says White, is “part of being human”: “It’s what some of us came into the world with a predisposition for.
It’s something we have to manage and struggle our way through, but not anything to become alarmed by”. She says there is no need to be silent about loneliness, and the shame and self-blame it creates. “There’s nothing wrong with loneliness, and we need to start acknowledging this through a wider and more open discussion of the state,” she adds.Sources: Ray Hainer, “Loneliness Hurts the Heart”, health.com, 21 Jun 2009; Jaap Spreeuw and Xu Wang, “Modelling the short-term dependence between two remaining lifetimes”, actuaries.org.uk 27 March 2008; D A Bennett et al, “The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study”, Lancet Neurology May 2006; Emily White’s blog, www.lonelythebook.com/loneliness-blog/; John Steinbeck, “Of Mice and Men”, Penguin Modern Classic 1993, Kindle edition; Jennifer Senior “Alone Together: Is Urban Loneliness a Myth”, New York Magazine, 23 Nov 2008; James Lynch “A Cry Unheard: New Insights into the Medical Consequences of Loneliness”, Bancroft Press, June 2000; Victoria Stern, “Loneliness May Lead to Serious Illness, including Cancer”, Scientific American, 29 May 2008; “The reason loneliness could be bad for your health”, The Economist, 24 Feb 2011; US Census Bureau “Families and Living Arrangements: 2005”; Age Concern, 2008 “Being socially excluded and living alone in old age. Findings from the English Longitudinal Study of Ageing (ELSA).”; Rosemary Bennett and Mary Bowers, “Loneliness: the silent epidemic sweeping through Britain”, The Times, 31 December 2009; http://scienceofloneliness.com; MIND.org.uk (website page: Diagnoses and conditions: Loneliness); Richard Booth “Loneliness as a Component of Psychiatric Disorders”. Medscape General Medicine 2(2), 2000; Kenneth M. Cramer and Joanne E. Barry, “Conceptualizations and measures of loneliness: a comparison of subscales”, Personality and Individual Differences, 27 (3), Sep 1999; Anthony Storr, “Solitude: A Return to the Self”, HarperCollins, 1989; “Single and Loving It, Even During the Holidays”, Newsweek, 22 Dec 2009. Written by: Catharine Paddock, PhD” “Antibiotic resistance is a growing concern across the globe; last year, the World Health Organization warned that we are heading toward a “post-antibiotic era” unless more is done to tackle the problem. Now, researchers find that an existing drug used to treat breast cancer may be effective against one of the most common superbugs: MRSA. Published in the journal Nature Communications, the study reveals how the drug tamoxifen boosted the immune system in order to reduce MRSA (methicillin-resistant Staphylococcus aureus) infection in mice. MRSA is one of the most common causes of health care-associated infections in the US, responsible for a number of severe illnesses, including pneumonia, bloodstream infections and skin and wound infections. According to the Centers for Disease Control and Prevention (CDC), there are more than 80,000 invasive MRSA infections in the US every year and more than 11,000 deaths from the condition. MRSA is a growing threat to public health because it is resistant to many antibiotics, making it hard to treat and significantly more life-threatening; people with MRSA are 64% more likely to die than individuals with a nonresistant form of S. aureus infection, claim the World Health Organization (WHO). While global leaders have stressed the need for the development of a new generation of antibiotics, researchers have been investigating how existing drugs could be used to tackle antibiotic resistance. “The threat of multidrug-resistant bacterial pathogens is growing, yet the pipeline of new antibiotics is drying up,” notes senior study author Dr. Victor Nizet, professor of pediatrics and pharmacy at the University of California-San Diego. “We need to open the medicine cabinet and take a closer look at the potential infection-fighting properties of other drugs that we already know are safe for patients.” Tamoxifen is a drug currently used to treat hormone receptor-positive breast cancer.
It works by binding to receptors for the hormone estrogen, which some breast cancers require to grow. “,Learn more about antibiotic resistance,” However, there is more to tamoxifen. Previous research has indicated that the drug affects how cells produce fatty molecules called sphingolipids, which play a role in the regulation of neutrophils – white blood cells that help to stave off infections, particularly bacterial infections. With this in mind, Dr. Nizet and colleagues set out to determine whether tamoxifen may be effective against MRSA by influencing the behavior of neutrophils. First, the team treated human neutrophils with tamoxifen. Compared with untreated neutrophils, they found the tamoxifen-treated neutrophils were not only better at targeting and engulfing bacteria, but also they created around three times as many neutrophil extracellular traps (NETs) – an abundance of DNA, enzymes and proteins that neutrophils send to trap and kill pathogens. The team found that other estrogen-targeting drugs failed to have the same effect on neutrophils as tamoxifen, and further research revealed that tamoxifen works by influencing the activity of a particular sphingolipid called ceramide to boost neutrophil activity. Next, the researchers tested the effect of tamoxifen in mice, which were treated with either tamoxifen or a control drug 1 hour before being infected with MRSA and 8 hours after. The team monitored the mice for 5 days. While the mice given the control drug failed to survive longer than 1 day after infection with MRSA, 35% of the mice treated with tamoxifen lived for 5 days after infection. What is more, levels of MRSA were around five times lower in the peritoneal fluid – liquid that accumulates in the abdominal cavity – of the tamoxifen-treated mice, compared with the control mice. Commenting on the findings, Dr.
Nizet says: “,“[…] We discovered that tamoxifen has pharmacological properties that could aid the immune system in cases where a patient is immunocompromised or where traditional antibiotics have otherwise failed.”,” While tamoxifen appears to be a potential treatment strategy for MRSA, the researchers point out that the drug’s effects on other antibiotic-resistant bacteria may vary because some bacteria have evolved to avoid NETs. The team also notes that their study highlights a potential downfall of tamoxifen for individuals who already take it to treat breast cancer. They explain that excess NET production in the absence of infection could be dangerous, with previous research associating it with inflammatory diseases, such as bronchial asthma and vasculitis – inflammation of the blood vessels. “While known for its efficacy against breast cancer cells, many other cell types are also exposed to tamoxifen. The ‘off-target effects’ we identified in this study could have critical clinical implications given the large number of patients who take tamoxifen, often every day for years,” says Dr. Nizet. Earlier this year, Medical News Today reported on a study published in The Lancet, in which researchers claimed a class of hormonal drugs known as aromatase inhibitors are more effective than tamoxifen for reducing mortality in breast cancer patients. “, “The number of U.S. children who have skin and food allergies has risen significantly in the last few years, a new government report by the CDC reveals. Surprisingly, the incidence of respiratory and food allergies increased with income: kids living in families that earned more than 200% of the poverty level had the highest rates, statistics suggested.
Report author LaJeana Howie, from the U.S. National Center for Health Statistics (NCHS), part of the U.S. Centers for Disease Control and Prevention, said:”,“The prevalence of food and skin allergies both increased over the past 14 years. This has been a consistent trend.”, Allergies are among the most common medical conditions that affect kids in the U.S. An allergic condition is defined as a hypersensitivity disorder in which the immune system responds to certain substances in the environment that are generally considered nontoxic. The most common allergies among kids are:,” Allergies can impact a child’s physical and emotional health and can hinder normal daily activities like play, sleep, and going to school. A serious allergic reaction with quick onset anaphylaxis can be dangerous.”, Foods are the most common cause of anaphylaxis among teenagers and children. Finding these allergies early in kids as well as making the correct interventions can help to reduce the negative outcomes on quality of life. The report revealed the following results in regards to allergies among children:,” Authors also noticed racial trends in their data. For example, they saw that Hispanic children had the lowest incidence of skin, food, and respiratory allergies, compared with other groups.
African American children were more likely to have skin allergies than white children (17.4% versus 12%), however, they were less likely to have respiratory allergies (15.6% versus 19.1%). Additionally, age was also an element in the incidence of skin and respiratory allergies. Among This trend was opposite for respiratory allergies: 10.8% of those aged 4 and under had them, 17.4% of those aged 5 to 9 had them and 20.8% of those aged 10 to 17.skin allergies, the rate fell with age: 14.2% of those aged 4 or younger had them, 13.1% of those aged 5 to 9 had them, and 10.9% of those aged 10 to 17. Lastly, income also played a role. Among households bringing in less than 100% of poverty level, 4.4% of those kids had food allergies and 14.9% had respiratory allergies. Among households making more than 200% of poverty level, 5.4% of those kids had food allergies and 18.3% had respiratory allergies. In 2011, the Northwestern University Feinberg School of Medicine reported that 5.9 million kids in the U.S. have food allergies.
Among this number, 30.4% are allergic to many foods, and 38.7% of those have severe reactions. Another study published in JAMA suggested that foreign born children who move to live in the U.S. have a lower risk of allergic diseases. The longer they live in the U.S., the greater their risk for these conditions becomes. Written by Kelly FitzgeraldIn this article, learn about some top baby detergents. This article lists options for newborns, for babies with sensitive skin, and for those with…Allergic reactions are common in babies and may occur as a result of irritants, bug bites, certain foods, or underlying skin conditions. Allergies can…”,There are a number of reasons why a child may have a dry cough. Learn more about some of these causes and the treatment options here.,Singulair is a medication that people commonly use to prevent asthma attacks and allergy symptoms. It works by blocking the molecules that trigger…,”Nosebleeds are a common problem, but they often subside quickly with at-home treatment. In this article, learn how to stop a nosebleed at home. We…” “For over thirty years research has been done and much debate has carried on about the benefits or risks associated with drinking alcohol and wine in particular.
After an analysis of research since 1977, it has been determined that drinking moderate amounts of alcohol, especially wine, may lower the risk of dementia which often leads to severe Alzheimer’s Disease. Too much increases the risk so balance is necessary. As a matter of fact, the association between moderate drinking and reduced risk of dementia and cognitive impairment was statistically significant in 14 of 19 countries, including the United States. Resveratrol, found in wine at fairly high levels, is a naturally occurring antioxidant too that decreases the stickiness of blood platelets and helps blood vessels remain open and flexible. It is also known that it inhibits the enzymes that can stimulate cancer cell growth and suppress immune response. Wine is the primary dietary source of resveratrol, and red wine contains much greater amounts of resveratrol than does white wine, since resveratrol is concentrated in the grape skin and the manufacturing process of red wine includes prolonged contact with grape skins.